Cystoscopy CPT Code Guide 2025 | Billing & Documentation Tips

Q: What is the CPT code for flexible diagnostic cystoscopy?

The code is 52000 , used when no biopsy or treatment is performed.

Understanding the right Cystoscopy CPT Code is crucial for accurate billing, compliance, and patient care. Whether you are a urologist, coder, or billing manager, coding cystoscopy correctly ensures smooth reimbursement and avoids denials.

This 2025 comprehensive guide explains the most commonly used cystoscopy CPT codes, their descriptions, billing guidelines, and documentation requirements, plus the latest payer updates.

What Is a Cystoscopy?

A cystoscopy is a minimally invasive procedure where a urologist examines the bladder and urethra using a scope. It may be:

Diagnostic (e.g., evaluating hematuria or bladder pain)
Therapeutic (e.g., biopsy, clot evacuation, Botox injection, or stent placement)

Since multiple services may occur in a single encounter, selecting the correct cystoscopy CPT code is essential for compliance.

Commonly Used Cystoscopy CPT Codes (2025 Update)

CPT Code	Description
52000	Diagnostic cystoscopy (flexible or rigid)
52204	Cystoscopy with bladder biopsy
52310 / 52315	Cystoscopy with stent removal
52332	Cystoscopy with ureteral stent placement
52224	Cystoscopy with fulguration of bladder tumor
52287	Cystoscopy with botulinum toxin (Botox) injection
52235–52240	Cystoscopy with clot evacuation or tumor removal

2025 Update: Medicare and commercial payers are enforcing stricter bundling rules. If performing multiple cystoscopy-related services, documentation and modifiers (-59, -XS) are critical for proper reimbursement.

CPT Code 52000 – Diagnostic Cystoscopy

CPT Code: 52000
Descriptor: “Cystourethroscopy (separate procedure)”
Usage: For diagnostic cystoscopy only. Do not bill 52000 with therapeutic procedures (e.g., biopsy, stent placement).

Billing Tip: You cannot bill CPT 52000 with another cystoscopy code on the same date unless you append modifier -59 or -XS to justify separate services.

Is CPT 52000 a Surgery Code?

Yes, CPT 52000 is categorized under surgical procedures, even though it’s diagnostic in nature. It falls under endoscopy procedures in the urology section of CPT coding.

But keep in mind this doesn’t always mean operating room usage. It may be executed in-office or outpatient.

Key Procedure Scenarios and Codes

Flexible Cystoscopy CPT Code

Use 52000 for flexible diagnostic cystoscopy if no biopsy or treatment is performed.

Cystoscopy with Bladder Biopsy CPT Code

Use 52204 when a biopsy is performed.
Do not separately bill 52000 in this case.

Cystoscopy with Stent Placement CPT Code

Use 52332 for ureteral stent placement.
Append -LT or -RT modifiers for laterality.

Cystoscopy with Botox Injection CPT Code

Use 52287 for botulinum toxin injection.
Also bill J0585 for Botox drug supply.

Cystoscopy with Clot Evacuation CPT Code

Codes 52235–52240 are used for clot evacuation or tumor removal.
Documentation must specify extent and complexity.

Midurethral Sling + Cystoscopy CPT Code

Use 57288 for the sling procedure.
Add 52000 for intraoperative cystoscopy, with modifier -51 or -59.

Documentation Requirements for Cystoscopy CPT Codes

Clear documentation prevents denials. Ensure notes include:

Indication: Hematuria, bladder tumor, recurrent UTIs, strictures
Type of cystoscopy: Flexible, rigid, blue light, laparoscopic
Procedures performed: Biopsy, stent placement, Botox injection
Laterality: Left, right, bilateral
Findings/complications: Stones, tumors, bleeding

Why Accurate Cystoscopy Coding Matters

For Providers: Reduces compliance risks and ensures payer alignment
For Billing Teams: Minimizes denials, accelerates payments
For Patients: Avoids unexpected bills due to coding errors

According to the American Urological Association (AUA, 2024), cystoscopy is one of the top 5 most billed urology procedures, making precise coding vital for revenue cycle management.

Why Accurate Cystoscopy Coding Matters

For providers: Ensures compliance with payer rules and protects against audits.
For billing managers: Reduces denials and speeds up reimbursement.
For patients: Prevents surprise bills due to incorrect coding.

According to the American Urological Association (AUA, 2024 update), cystoscopy is among the top five urology procedures billed annually, making coding precision a revenue-cycle priority.

American Urological Association (AUA) – Cystoscopy Guidelines

Final Thoughts

Mastering the correct Cystoscopy CPT Code in 2025 ensures accurate billing, reduces denials, and improves compliance. From diagnostic cystoscopy (52000) to more complex procedures like bladder biopsy or Botox injection, correct coding is a cornerstone of successful urology billing.

We help providers and billing teams stay updated on CPT changes, payer rules, and documentation standards. Express MBS, support providers with denial management and coding audits.